Monoamine Transporter

Related Products

Monoamine transporters (MATs) belong to the solute carrier 6 (SLC6) family of human transporters, which, in turn, is a subfamily of the broader neurotransmitter:sodium symporters (NSSs) that comprise transporters from prokaryotic to human. MATs comprise three main members-the dopamine (DA) transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET). MATs regulate neurotransmission via the reuptake of dopamine, serotonin and norepinephrine from extra-neuronal regions and thus maintain neurotransmitter homeostasis.

MATs are transmembrane proteins located in plasma membranes of monoaminergic neurons. These proteins use ion (Na⁺, Cl⁻) gradients as energy sources to move monoamines into or out of neurons. In the membrane of intracellular synaptic vesicles is the vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2), which use a proton gradient as the energy source to sequester cytosolic monoamines into the vesicles and then release the monoamines into synaptic cleft by exocytosis. Dysregulation of MATs has been linked to depression, anxiety disorder, attention-deficit-hyperactivity disorder, obsessive-compulsive disorder, substance-use disorders, epilepsy, Parkinson’s disease and autism-spectrum disorder. Thus, MATs serve as pharmacological targets for several neuropsychiatric and neurodegenerative disorders.

Monoamine Transporter Inhibitors (39)

Monoamine Transporter Related Products (51):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-131006

FFN200 dihydrochloride		≥99.0%
FFN200 dihydrochloride, a fluorescent substrate of VMAT2, selectively trace monoamine exocytosis in both neuronal cell culture and brain tissue. The fluorescence excitation and emission maxima of FFN200 are determined to be 352 and 451 nm, respectively.

HY-103465

FFN511	Inhibitor	99.40%
FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC₅₀ of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices.

HY-B0590S1

(+)-Tetrabenazine-d₆
(+)-Tetrabenazine-d₆ is the deuterium labeled (+)-Tetrabenazine. (+)-Tetrabenazine is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2).

HY-B0590E

Tetrabenazine mesylate	Inhibitor
Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the K_d value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

HY-N0480S

Reserpine-d₉	Inhibitor
Reserpine-d₉ is the deuterium labeled Reserpine. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

HY-145577A

Lafadofensine (D-(-)-Mandelic acid)	Inhibitor	99.95%
Lafadofensine D-(-)-Mandelic acid is the monoamines reuptake inhibitor. Lafadofensine D-(-)-Mandelic acid has sufficient effects after short-term administration.

HY-148863

Cavα2δ1&NET-IN-2	Inhibitor
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Ca_vα2δ-1 with a K_i of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a K_i of 59 nM and IC₅₀ of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain.

HY-103217

Talopram hydrochloride	Inhibitor
Talopram hydrochloride is a selective inhibitor for norepinephrine transporter (NET), that inhibits 63% human NET at 100 nM.

HY-148862

Cavα2δ1&NET-IN-1	Inhibitor
Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Ca_vα2δ-1 with a K_i of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a K_i of 383 nM and IC₅₀ of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain.

HY-16771A

Valbenazine tosylate	Inhibitor
Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the K_i of 110-190 nM.

HY-G0025

Tetrabenazine Metabolite	Inhibitor
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (K_i=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.

HY-161433

VMAT2-IN-3	Inhibitor
VMAT2-IN-3 (compound 10) is a potent vesicular monoamine transporter-2 (VMAT2) inhibitor with a K_i of 0.71 nM. VMAT2-IN-3 has the potential for neurological or psychiatric disease research.

HY-153472

VMAT2-IN-2 tosylate	Inhibitor
VMAT2-IN-2 tosylate is a potent VMAT2 inhibitor. VMAT2-IN-2 tosylate can be used in research of tardive dyskinesia.

HY-15793A

Trans (2,3)-Dihydrotetrabenazine	Inhibitor
Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).

HY-B0590S3

Tetrabenazine-d₇	Inhibitor
Tetrabenazine-d₇ (TBZ-d₇-d₇) is deuterium labeled Tetrabenazine. Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the K_d value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

HY-N7506

13-Hydroxyisobakuchiol	Inhibitor
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀=0.58 μM) and norepinephrine transporter (NET) (IC₅₀=0.69 μM) than for the serotonin transporter (SERT) (IC₅₀=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression.

HY-107956

Imipramine pamoate
Imipramine pamoate is a potent anti-depressant compound.

HY-W681822

(R,S,S)-Dihydrotetrabenazine	Inhibitor
(R,S,S)-Dihydrotetrabenazine (R,S,S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (K_i = 690 nM).

HY-172029

3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride
3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT), serotonin transporter (SERT), and the norepinephrine transporter (NET).

HY-W743021

4-Methyl-α-ethyltryptamine
4-Methyl-α-ethyltryptamine is a homolog of α-Ethyltryptamine. α-Ethyltryptamine alters monoamine release and re-uptake in the brain.

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